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Basic Science

Oral Abstract Presentation Session l Basic Science / Health Services

Palmitoylethanolamide modulates gait and hyperalgesia in sickle mice

Sunday, June 18, 2023
1:45 PM - 2:00 PM East Coast USA Time
Location: Grand Salons C-D

    Speaker(s)

  • Kendall O'Daniel, B.S.

    Junior Specialist
    University of California, Irvine
    University of California, Irvine
    long beach, California, United States

    Slides

    • First Author(s)

  • Kendall O'Daniel, B.S.

    Junior Specialist
    University of California, Irvine
    University of California, Irvine
    long beach, California, United States

    Slides

    • Author(s)

  • KP

    Kristen Peterson, B.S.

    Junior Specialist
    University of California, Irvine, California, United States

  • DA

    Donovan A. Argueta, Ph.D.

    Postdoctoral Scholar
    University of California, Irvine
    University of California, Irvine
    Los Angeles, California, United States

  • MA

    Mya A. Arellano, B.S.

    Junior Specialist
    University of California, Irvine, California, United States

  • RF

    Raghda T. Fouda, M.D., PhD

    Postdoctoral Scholar
    University of California, Irvine, California, United States

  • NG

    Natalie R. Garcia, B.S.

    Junior Specialist
    University of California, Irvine, California, United States

    • Corresponding Author(s)

  • Kalpna Gupta, PhD

    Professor of Medicine
    University of California, Irvine
    University of California, Irvine
    Long Beach, California, United States

Disclosure(s):
Kendall O'Daniel, B.S.: No financial relationships to disclose
Kalpna Gupta, PhD: No relevant disclosure to display

Learning Objectives:

  • We provide the first evidence that palitoylamethanolamide (PEA) administration in humanized sickle mouse model improves features of gait and inflammation.
  • Neurological, neuropathic, and immunological factors may contribute to peripheral and central mechanisms that drive dysfunction in sickle cell disease, including Purkinje cell damage and chronic inflammation
  • Palitoylamethanolamide (PEA) has analgesic and anti-inflammatory effects on chronic pain in several clinical conditions, which includes reduction of mast cell activation-a key mechanism underlying pain and hypersensitivity in sickle cell disease.
  • Dysfunctional gait associated with chronic pain is a debilitating comorbidity of sickle cell disease. We perform gait analysis using an automated system called MouseWalker to evaluate the effect of palitoylamethanolamide on pain related gait impairments.