Tweets by FSCDR's 17th Annual SCD Research and Educational Symposium & 46th Nat'l SCD Scientific Meeting

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Basic Science

Oral Abstract Presentation Session l Basic Science / Health Services

Targeting sickle cell pathobiology and pain with novel transdermal curcumin

Sunday, June 18, 2023

1:30 PM – 1:45 PM East Coast USA Time

Location: Grand Salons C-D

Speaker(s)

Yugal Goel, PhD

Postdoctoral Scholar
University of California, Irvine
University of California, Irvine
Long Beach, California, United States

Slides

First Author(s)

Yugal Goel, PhD

Postdoctoral Scholar
University of California, Irvine
University of California, Irvine
Long Beach, California, United States

Slides

Author(s)

MA

Mya A. Arellano, B.S.

Junior Specialist
University of California, Irvine, California, United States
RF

Raghda T. Fouda, M.D., PhD

Postdoctoral Scholar
University of California, Irvine, California, United States
NG

Natalie R. Garcia, B.S.

Junior Specialist
University of California, Irvine, California, United States
Reina A. Lomeli (she/her/hers)

Junior Specialist
University of California, Irvine
Lancaster, California, United States
GV

Graham J. Velasco, HTL (ASCP) QIHC, MSHCA

Anatomic Pathology Supervisor
VA Long Beach Healthcare System, California, United States
DK

Daniel J. Kerr, PhD

Adjunct Assistant Professor
City University of New York, New York, United States
PB

Probal Banerjee, PhD

Professor
City University of New York, New York, United States
DA

Donovan A. Argueta, Ph.D.

Postdoctoral Scholar
University of California, Irvine
University of California, Irvine
Los Angeles, California, United States
MG

Mihir Gupta, M.D.

Assistant of Orthopaedic Surgery
Johns Hopkins University, Maryland, United States
JF

Joel M. Friedman, M.D., PhD

Professor
Albert Einstein College of Medicine, New York, United States

Corresponding Author(s)

Kalpna Gupta, PhD

Professor of Medicine
University of California, Irvine
University of California, Irvine
Long Beach, California, United States

Disclosure(s):

Reina A. Lomeli, B.S.: No financial relationships to disclose

Kalpna Gupta, PhD: No relevant disclosure to display

Learning Objectives:

Study describes novel transdermal curcumin shows high bioavailability.
Transdermal curcumin reduces hyperalgesia in sickle mice upon acute and chronic treatment.
Transdermal curcumin administration on sickle mice inhibits mast cell degranulation, inflammation and cytokine storm .
Transdermal curcumin application on sickle mice reduces hemolysis and improves features of anemia suggestive of a disease modifying effect.
Transdermal curcumin offers a safe, non-toxic and economically viable intervention for treating and maybe preventing pain in sickle cell disease.