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Basic Science

Oral Abstract Presentation Session l Basic Science / Health Services

PB-04 Reduces Multi-Organ Pathology & Hydroxyurea-Associated Cytopenias in Transgenic Sickle Mice

Sunday, June 18, 2023
2:00 PM – 2:15 PM East Coast USA Time
Location: Grand Salons C-D

    Speaker(s)

  • Susan P. Perrine, MD, SM

    Chief Medical Officer and Professor
    Phoenicia BioSciences, Boston University Chobanian & Avedisian School of Medciine
    Boston University Chobanian & Avedisian School of Medicine
    Weston, Massachusetts, United States

    • First Author(s)

  • BP

    Betty S. Pace, MD

    Professor
    Augusta University
    Augusta, Georgia, United States

    • Author(s)

  • MP

    Monika Pilichowska, MD, PhD

    Associate Professor
    Tufts University School of Medicine, Tufts Medical Center,Pathology & Laboratory Medicine
    Boston, Massachusetts, United States

  • MT

    Mayuko Takezaki, MS

    Research Associate
    Augusta University
    Augusta, Georgia, United States

  • BL

    Biarou Li, PhD

    Reesearch Associate
    Augusta University
    Augusta, Georgia, United States

  • AF

    Aidan D. Faller, BS

    Research Associate, Clinical Research Coordinator
    Phoeniica Bioscince, Massachusetts General Hospital
    Weston, Massachusetts, United States

    • Corresponding Author(s)

  • Susan P. Perrine, MD, SM

    Chief Medical Officer and Professor
    Phoenicia BioSciences, Boston University Chobanian & Avedisian School of Medciine
    Boston University Chobanian & Avedisian School of Medicine
    Weston, Massachusetts, United States

Disclosure(s):
Susan P. Perrine, MD, SM: No financial relationships to disclose

Learning Objectives:

  • List abnormalities observed in red blood cells, the lungs, and the spleen in transgenic murine sickle cell disease
  • List 2 beneficial changes observed with hydroxyurea in murine sickle cell disease
  • List an effect of Hydroxyurea on hematopoiesis in murine sickle cell disease that often limits optimal dosing in human sickle cell disease
  • List 2 favorable changes observed in murine sickle cell disease with a therapeutic in clinical trials